Is a healthy lifestyle the key to longevity?

Is a healthy lifestyle the key to longevity?



Our aging process is not well understood. We often ask ourselves why we age and whether we can prolong life. This video explores telomeres as a possible explanation as to why we age. Telomeres are protective caps at the ends of DNA strands that shorten over time. Many factors and environmental stressors can accelerate this process. Lifestyle choices including diet and exercise can slow the aging process down and potentially prolong life.

This video was made by McMaster Demystifying Medicine students (Ahmad) Zubair Banoor, Vanessa Sheng, Lavan Sivarajah and Danil Kopylov.

Copyright McMaster University 2017

Please let us know how you liked this video and suggest additional topics for us to demystify below.

References:

Boccardi, V. Paolisso, G., & Mecocci, P. (2016). Nutrition and lifestyle in healthy aging: the telomerase challenge. Aging, 8(1), 12-15.

Chan, S.R.W.L., & Blackburn, E.H. (2003). Telomeres and telomerase. Phil Trans R Soc Lond, 359, 109-121.

Crous-Bou, M., Fung, T.T., Prescott, J., Julin, B., Du, M., Sun, Q., Rexrode, K.M., Hu, F.B., & De Vivo, I. (2014). Mediterranean diet and telomere length in Nurses’ Health Study: population-based cohort study. BMJ, 348.

Epel, E. Daubenmier, J., Moskowitz, J.T. Folkman, S., & Blackburn, E. (2009). Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres. Ann N Y Acad Sci, 1172, 34-53.
Farzaneh-Far, R., Lin, J., Epel., E.S., Harris, W.S., Blackburn, E.H., & Whooley, M.A. (2010). Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease. JAMA, 303(30), 250-257.

Kalmbach, K.H., Antunes, D.M.F., Dracxler, R.C., Knier, T.W., Seth-Smith, M.L., Wang, F., Liu, L., & Keefe, L. (2013). Telomeres and human reproduction. Fertil Steril, 99(1).
Khan, S. (2012). Telomeres and atherosclerosis. Cardiovasc J Afr, 23(10), 563-571.
Martin, A.A., Dionne, I., Wellinger, R.J., & Holm, C. (2000). The Function of DNA Polymerase α at Telomeric G Tails Is Important for Telomere Homeostasis. Mol Cell Bio, 20(3), 786-796.
Mundstock, E., Zatti, H. Louzada, F.M., Oliveira, S.G., Guma, F.T.C.R., Paris, M.M., Rueda, A.B., Machado, D.G., Stein, R.T., Jones, M.H., Sarria, E.E., Barbé-Tuana, F.M., & Mattiello, R. (2015). Effects of physical activity in telomere length: Systematic review and meta-analysis. Ageing Research Reviews, 22, 72-80.
Shay, J.W., & Wright, W.E. (2000). Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol, 1(1), 72-76.

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